Cnidaria asked:
A phenotypically normal prospective couple seeks genetic counseling because the man knows that he has a translocation of a portion of his chromosome 4 that has been exchanged with a portion of his chromosome 12. Although he is normal because his translocation is balanced, he and his wife want to know the probability that his sperm will be abnormal. What is your prognosis regarding his sperm?
A phenotypically normal prospective couple seeks genetic counseling because the man knows that he has a translocation of a portion of his chromosome 4 that has been exchanged with a portion of his chromosome 12. Although he is normal because his translocation is balanced, he and his wife want to know the probability that his sperm will be abnormal. What is your prognosis regarding his sperm?
B) All will carry the same translocation as the father.
C) 1/4 will be normal, 1/4 with the translocation, 1/2 with duplications and deletions.
D) None will carry the translocation since abnormal sperm will die.
E) His sperm will be sterile and the couple might consider adoption
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C) 1/4 will be normal, 1/4 with the translocation, 1/2 with duplications and deletions.
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B is untrue, D is untrue and E is untrue.
C is your answer.
The duplications and deletions arise from having one of the abnormal chromosomes, but not the other.
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